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Cyproterone Racha 100

Cyproterone Racha 100

Classification: Hormone

Composition: "Each tablet contains: Cyproterone acetate 100 mg"

Indications: "Management of patients with prostatic cancer: 1. To suppress ""flare"" with initial LHRH analogue therapy, 2. In long-term palliative treatment where LHRH analogues or surgery are contraindicated, not tolerated, or where oral therapy is preferred. 3. In the treatment of hot flushes in patients under treatment with LHRH analogues or who have had orchidectomy."

Adverse Reactions: "• The most frequently observed reactions in patients receiving cyproterone are decreased libido, erectile dysfunction and reversible inhibition of spermatogenesis. • The most serious reactions in patients receiving cyproterone are hepatic toxicity, benign and malignant liver tumourswhich may lead to intra-abdominal haemorrhage and thromboembolic events. • The following incidences were estimated from small number of clinical trials and spontaneous adverse reactions reports: Very common: Decreased libido, erectile dysfunction, reduced sexual drive and inhibition of gonadal function. These changes are reversible after discontinuation of therapy, Sperm count and the volume of ejaculate are reduced (Infertility is usual, and there may be azoospermia after 8 weeks. Follow-up examinations have shown these changes to be reversible, spermatogenesis usually reverting to its previous state about 3-5 months after stopping cyproterone, or in some users, up to 20 months. That spermatogenesis can recover even after very long treatment is not yet known. There is evidence that abnormal sperms which might give rise to malformed embryos are produced during treatment with cyproterone), Common: Changes in bodyweight during long term treatment, Depressive moods and restlessness (temporary), Dyspnoea, Direct hepatic toxicity (Toxicity is dose related and develops, usually, several months after treatment has begun), Gynaecomastia (which usually regresses after withdrawal of the preparation), Hot flushes, sweating, fatigue and lassitude Uncommon: Rash. "

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